モノクローナル抗HNK-1/N-CAM(CD57)抗体 マウス宿主抗体

モノクローナル抗HNK-1/N-CAM(CD57)抗体 マウス宿主抗体 価格

モノクローナル抗HNK-1/N-CAM(CD57)抗体 マウス宿主抗体 化学特性,用途語,生産方法

• 使用

  Monoclonal Anti-HNK-1/N-CAM (CD57) antibody produced in mouse has been used:
  
  • as primary antibody for western blot analysis
  • immunocytochemistry
  • immunocytochemical
  • immunohistological staining
  
  

• 一般的な説明

  Monoclonal Anti-HNK-1/N-CAM (CD57) (mouse IgM isotype) is derived from the VC1.1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Human natural killer cell -1 (HNK-1), also referred as B3GAT1, NK1, CD57, LEU7, NK-1, GLCATP and GLCUATP, is mapped to human chromosome 11q25. The encoded protein belongs to the glucuronyltransferase gene family. Neural cell-adhesion molecule (N-CAM) is expressed on all neuroepithelial cells from the time of neural induction in the early embryo. It is known that the sulfated carbohydrate HNK-1 epitope is carried by several surface molecules including a proportion of N-CAM isoforms.

• Biochem/physiol Actions

  HNK1 (human natural killer-1) is referred as B3GAT1, NK1, CD57, LEU7, NK-1, GLCATP and GLCUATP. It is a member of the glucuronyltransferase gene family. Human natural killer-1 (HNK1) carbohydrate epitope is expressed on various cell adhesion molecules in the nervous system and plays a role in cell-cell and cell-substrate interactions. HNK-1 epitope stabilizes GluR2 on neuronal surface membranes and regulates cell surface stability of GluR2 by modulating the interaction with N-cadherin. It is also plays a role in cell migration and synaptic plasticity. HNK-1 epitope has been associated with the risk of metastasis. It is observed to be highly expressed in melanoma cell lines.

モノクローナル抗HNK-1/N-CAM(CD57)抗体 マウス宿主抗体 生産企業

Global(38)Suppliers