N-カルボベンゾキシ-L-プロリン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H318：重篤な眼の損傷

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

N-カルボベンゾキシ-L-プロリン 価格

MSDS Information

• Z-Pro-OH

N-カルボベンゾキシ-L-プロリン 化学特性,用途語,生産方法

• 外観

  白色～微黄色, 結晶性粉末～粉末

• 用途

  ペプチド合成用原料。

• 化学的特性

  white to light yellow crystal powder

• 使用

  N-(Benzyloxycarbonyl)-L-proline is a potent in vitro and in vivo inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. It is also used in the synthesis of N-(L-Prolyl)-β-alanine which is a derivative of the naturally occurring beta amino acid β-Alanine.

• 製造方法

  Caution! All procedures must be carried out in an efficient fume cupboard, wearing latex gloves and chemical-proof safety goggles. ι-Proline (10.0 g, 8.7 mmol) was dissolved in 2 m sodium hydroxide solution (40 mL), and the solution was cooled to ice-water temperature. Z-Cl (20.5 g, 12 mmol) was added portionwise, with vigorous stirring or occasional shaking, over a period of 30 min at 0–5 °C to the solution of l-proline. The ice bath was then removed and stirring or occasional shaking was continued for 30 min while the reaction mixture warmed to room temperature. The mixture was then acidified to Congo red by the gradual addition of concentrated hydrochloric acid, and the oil was extracted into ethyl acetate. The extract was dried over magnesium sulfate, the mixture was filtered, and the filtrate was concentrated in vacuo. The residue was extracted/triturated with warm tetrachloromethane. The washings were decanted and the residue was further purified by recrystallization from ethyl acetate/petroleum ether.

N-カルボベンゾキシ-L-プロリン 上流と下流の製品情報

N-カルボベンゾキシ-L-プロリン 生産企業

Global(512)Suppliers

N-カルボベンゾキシ-L-プロリン スペクトルデータ(IR1、IR2、MS、Raman)

1148-11-4, N-カルボベンゾキシ-L-プロリン キーワード