T0901317

T0901317 価格

T0901317 化学特性,用途語,生産方法

• 使用

  The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.

• 一般的な説明

  A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.

• 生物活性

  Potent, high affinity liver X receptor (LXR) agonist (EC 50 ~ 50 nM, Kd values are 7 and 22 nM for LXR- α and LRXR- β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid- β production in primary neurons in vitro . Displays an EC 50 of ~ 5 μ M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid.

T0901317 生産企業

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T0901317 スペクトルデータ(¹HNMR)

293754-55-9, T0901317 キーワード