抗ヒトIGM(Μ鎖特異的)抗体-アガロース結合 ヤギ宿主抗体

抗ヒトIGM(Μ鎖特異的)抗体-アガロース結合 ヤギ宿主抗体 化学特性,用途語,生産方法

• 使用

  Goat polyclonal anti-Human IgM (μ-chain specific)?Agarose antibody conjugate is used as an immuno-adsorbent to affinity purify antibodies, to remove species specific cross-reacting antibodies or to remove contaminating antibodies from an antiserum preparation. It has been used for IgM depletion from normal human serum from fasted patients.

• 一般的な説明

  Immunoglobulin M (IgM) antibodies appear early in the course of infections. IgM antibodies are responsible for agglutination of red blood cells in mis-matched blood transfusions. The level of IgM may vary with the status of disease or infection.
  Cyanogen bromide activated cross-linked beaded agarose is frequently conjugated to proteins such as immunoglobulins to facilitate their use in physicochemical processes such as precipitation, absorption and clarification.

• Biochem/physiol Actions

  IgM plays a key role in the engulfing of apoptotic cells. A reduction in serum IgM levels leads to increased autoimmune response and higher risk for infections. IgM displays polyreactive and autoreactive functionality. It plays a key role in tissue homeostasis by mediating clearance of tissue based molecules. IgM has sites for N-linked glycosylation, with sugars namely, mannose, galactose, N-acetyl glucosamine and sialic acid. IgM linked agarose resins have been tested for efficient conjugate binding.

抗ヒトIGM(Μ鎖特異的)抗体-アガロース結合 ヤギ宿主抗体 生産企業

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