Proteasome Inhibitor XVI

Proteasome Inhibitor XVI 化学特性,用途語,生産方法

• 一般的な説明

  A cell-permeable, peptide vinyl sulfone that acts as a potent, irreversible inhibitor of proteasome activity. Covalently modifies the catalytically active β-subunits of the proteasome. Shown to inhibit the chymotrypsin-like (10-50 nM), trypsin-like (1-5 μM), and the peptidyl glutamyl peptide hydrolyzing (PGPH) (0.5-1 μM) activities of purified 20S proteasomes from rabbit muscle. Inhibits proteasomal degradation of deglycosylated MHC HLA-A2 heavy chain in US11+ cells (~50 μM).

• Biochem/physiol Actions

  Cell permeable: yes

Proteasome Inhibitor XVI 生産企業

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