S14161

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

  P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けるこ と。

S14161 化学特性,用途語,生産方法

• 説明

  D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G₁ to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D₁-D₃ expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G₀/G₁ phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC₅₀s < 10 μM) but is less toxic to normal hematopoietic cells (IC₂₀ > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.

• 使用

  S14161 is a small-molecule inhibitor of D-cyclin transactivation that displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.

S14161 生産企業

Global(35)Suppliers

883046-50-2, S14161 キーワード