リトラニジン12-アセタート

リトラニジン12-アセタート 化学特性,用途語,生産方法

• 説明

  A non-crystallizable alkaloid isolated from Lythrum anceps Mak., the base yields a very hygroscopic hydrochloride and the O,O-diacetate, the latter giving a crystalline hydrochloride, m.p. 180-218°C (dec.); [α]²⁵_D - 33°. When hydrolyzedwith dilute alkalies, the alkaloid gives Lythranidine (q.v.) while treatment with formaldehyde yields Lythamine. Dehydrogenation with Pd-C followed by oxidiation with KMn04 furnishes dipicolinic acid.

• 参考文献

  Fujita et ai., Tetrahedron Lett., 4595 (1967) Fujita, Fuji, Tanaka., ibid, 5905 (1968) Fujita et ai., Chern. Pharrn. Bull., 18, 2216 (1970) Fujita, Fuji, Tanaka.,J. Chern. Soc., C, 205 (1971) Fujita, Fuji., ibid, 1651 (1971)