テルブタリン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H361：生殖能または胎児への悪影響のおそれの疑い

  H373：長期にわたる、または反復暴露により臓器の障 害のおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P281：指定された個人用保護具を使用すること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

  P314：気分が悪い時は、医師の診断/手当てを受けること。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

テルブタリン 価格

テルブタリン 化学特性,用途語,生産方法

• 用途

  β 受容体刺激薬気管支平滑筋を弛緩させる喘息治療薬

• 効能

  気管支拡張薬, β2アドレナリン受容体作動薬

• 説明

  Terbutaline is a synthetic congener of adrenaline that acts at the β2-receptor causing bronchodilation and tocolytic effects. It was the first β2-selective adrenoreceptor agonist in general clinical use. In 2011, the Food and Drug Administration (FDA) placed a black-boxed warning on terbutaline stating that terbutaline injections should not be given to pregnant women nor should be used to prevent preterm labor or for long-term (greater than 48–72 h) treatment of preterm labor. Oral terbutaline should not be used at all due to its potential for cardiac toxicity and death. Terbutaline is on the World Anti- Doping Agency’s list of prohibited drugs for Olympic athletes (except when a Therapeutic Use Exemption has been granted in advance and when used by inhalation).

• 使用

  Terbutaline is used for preventing and relieving bronchospasms in bronchial asthma, chronic bronchitis, pulmonary emphysema, and other broncho-pulmonary diseases.

• 適応症

  Terbutaline (Brethine, Bricanyl) is a relatively specific β₂-adrenoceptor agonist. Terbutaline can prevent premature labor, especially in individuals who are more than 20 weeks into gestation and have no indication of ruptured fetal membranes or in whom labor is not far advanced. Its effectiveness in premature labor after 33 weeks of gestation is much less clear. Terbutaline can decrease the frequency, intensity, and duration of uterine contractions through its ability to directly stimulate β₂-adrenoceptors. While it appears to be especially selective for β₂-receptor activation, terbutaline does have some β₁ activity as well.

• 定義

  ChEBI: A member of the class of phenylethanolamines that is catechol substuted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.

• 作用機序

  Terbutaline is a synthetic sympathomimetic amine. It is one of the most selective direct–acting stimulants of β2-adrenoreceptors. It stimulates smooth muscle β2-adrenoreceptors in the bronchi, relaxing them and relatively minutely acting on the β1—receptors of the heart.

• 臨床応用

  Terbutaline should be initially used only in an appropriate hospital setting where any obstetric complications can be readily addressed. After initial administration, it can be used in the outpatient setting. Concomitant use of β₂-adrenergic agonists and corticosteroids have additional diabetic effects and may rarely lead to pulmonary edema.The combination of β₂- adrenergic agonists and magnesium sulfate can cause cardiac disturbances, while coadministration of terbutaline with other sympathomimetics can lead to the potentiation of the actions of the latter drugs.

• 副作用

  Terbutaline is frequently used in the management of premature labor, although it has not been marketed for such use. Its effectiveness, side effects, precautions, and contraindications are similar to those of all β₂-adrenergic agonists. Terbutaline can cause tachycardia, hypotension, hyperglycemia, and hypokalemia. It can be given orally in addition to subcutaneous or intravenous administration.

• 環境運命予測

  Terbutaline is administered as the sulfate. It is a white to graywhite, crystalline powder; nearly odorless or with the faint odor of acetic acid. Terbutaline has a slightly bitter taste. It has a melting point of 247°C. Terbutaline sulfate is soluble at 1 g per 1.5 ml water or 250 ml of ethanol. It is soluble in 0.1 N hydrochloric acid, slightly soluble in methanol, and insoluble in chloroform. While terbutaline is stable under normal conditions as a solid, it is unstable in light. Terbutaline is degraded through oxidative processes; this is enhanced in the presence of trace levels of metals and in the presence of oxygen.
  No information is currently available on breakdown in soil, groundwater, or surface water.

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