Anti-PAD4, Anti-PADI5, Anti-PDI4, Anti-Peptidyl Arginine Deaminase Type IV, Anti-Peptidyl Arginine Deaminase V

Anti-PAD4, Anti-PADI5, Anti-PDI4, Anti-Peptidyl Arginine Deaminase Type IV, Anti-Peptidyl Arginine Deaminase V 化学特性,用途語,生産方法

• 使用

  Anti-PADI4 (N-terminal) antibody produced in rabbit has been used in immunohistochemistry and immunofluorescence.

• 一般的な説明

  PAD4 (also designated PADI4 or PAD type IV), one of the members of the PAD family. PAD4 was initially named PAD5. However, since it is closely related to rodent PAD4 it was renamed human PAD4. The most noticeable difference between the isotypes is their tissue-specific expression. Expression of the PAD4 gene is tightly linked to myeloid differentiation. It is expressed in granulocytes and monocytes and expressed in the nucleus.

• Biochem/physiol Actions

  Peptidyl arginine deiminase 4 (PADI4) is responsible for the post-translational conversion of peptidylarginine to citrulline, in the presence of calcium ions. In individuals with rheumatoid arthritis (RA), this gene is expressed in hematological cells and synovial tissues, and variant in this gene is linked with susceptibility to RA. The expression of this protein is linked with DNA hypermethylation in acute promyelocytic leukemia (APL).

Anti-PAD4, Anti-PADI5, Anti-PDI4, Anti-Peptidyl Arginine Deaminase Type IV, Anti-Peptidyl Arginine Deaminase V 生産企業

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