アンドロゲン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H302：飲み込むと有害

  H351：発がんのおそれの疑い

  H400：水生生物に強い毒性

• 注意書き

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P273：環境への放出を避けること。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

アンドロゲン 価格

MSDS Information

• 17-(1-Oxopropoxy)-(17b)-androst-4-en-3-one

アンドロゲン 化学特性,用途語,生産方法

• 外観

  白色～わずかにうすい黄色, 結晶～結晶性粉末

• 溶解性

  エタノール及びアセトンに溶け、水にほとんど溶けない。

• 解説

  男性ホルモン，雄性ホルモンともいう男性の副性器の活性の刺激，男性性欲の発達，去勢後の男性性徴の衰退の阻止などの活性を示す物質の総称で，通常はアンドロステロン，テストステロンなどの男性ホルモンを指す．

• 効能

  男性ホルモン補充薬, アンドロゲン受容体作動薬

• 化学的特性

  Testosterone Propionate occurs as white or almost white powder or colourless to pale yellow, crystals or crystalline powder. It is freely soluble in methanol and in ethanol, and practically insoluble in water.

• 使用

  Testosterone propionate is an is an androgen and anabolic steroid (AAS) medication, which directs the development of the male phenotype during embryogenesis and at puberty. It has been widely used by athletes and bodybuilders for physical performance enhancement. Testosterone propionate has also been used for studying its effects on pregnant ewes.

• 世界保健機関（WHO）

  In 1982, low dosage preparations of testosterone propionate, a synthetic ester of the naturally-occurring androgen, testosterone, were prohibited in Bangladesh following their inadmissable promotion as anabolic agents for use in malnourished children. Higher dosage preparations of testosterone propionate remain available in many countries, including Bangladesh, for several highly specific but limited indications including hypogonadism and the palliative treatment of inoperable breast cancer.

• 一般的な説明

  Testosterone propionate appears as odorless white or yellowish-white crystals or a white or creamy-white crystalline powder. (NTP, 1992)

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Testosterone propionate is sensitive to light. Incompatible with alkalis and oxidizing agents. .

• 火災危険

  Flash point data for Testosterone propionate are not available; however, Testosterone propionate is probably combustible.

• 安全性プロファイル

  with experimental neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion and wintraperitoneal routes. Human male reproductive effects by intramuscular and parenteral routes: changes in spermatogenesis, testes, epid~dpmis, and sperm duct. Human female reproductive effects by intramuscular and parenteral routes: menstrual cycle changes or disorders and effects on ferthty. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also TESTOSTERONE.

• 純化方法

  Crystallise the propionate from aqueous EtOH, or Et2O/pet ether (m 121o), and it has max at 240nm (EtOH), and [] 20 +114o (c 1, CHCl3). Also purify it by HPLC. [Ercol & de Ruggieri J Am Chem Soc 75 650, 652 1953, polymorphism: Brandst.tter-Kuhnert & Kofler Mickokim Acta 847, 850 1959, Beilstein 8 IV 977.]

• Mode of action

  Testosterone Propionate is a short acting oil-based injectable formulation of testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males.

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