(+)-1-[[(1R,9aβ)-オクタヒドロ-2H-キノリジン-1-イル]メチル]-2,6-ピペリジンジオン

(+)-1-[[(1R,9aβ)-オクタヒドロ-2H-キノリジン-1-イル]メチル]-2,6-ピペリジンジオン 化学特性,用途語,生産方法

• 説明

  The leaves of Lamprolobium fruticosum yields this alkaloid as a colourless oil, [α]²⁰_Do + 29° (EtOH) and furnishing a crystalline picrate, m.p. 153-4°C. Acid hydrolysis of the alkaloid yields glutaric acid and (+ )-l-aminoethylquinolizidine. The stereochemistry of the latter has been established by demonstrating the identity of the N-acetyl derivative, m.p. l44-5°C; [α]²⁰_Do + 46° (EtOH) with that prepared from epilupinine. The structure has been confirmed from the infrared, NMR and mass spectra. The total synthesis of the optically inactive alkaloid and its epimer has been carried out.

• 参考文献

  Hart, Johns, Lamberton., Chem. Commun., 302 (1968)
  Hart, Johns, Lamberton., Austral. J. Chem., 21, 1619 (1968)
  Synthesis:
  Jeffcoat., Diss. Abstr. Int., 30B, 4973 (1970)
  Yamada, Hatano, Matsui., Agr. Bioi. Chem., 34, 1536 (1970)

(+)-1-[[(1R,9aβ)-オクタヒドロ-2H-キノリジン-1-イル]メチル]-2,6-ピペリジンジオン 生産企業

Global(3)Suppliers