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Sucralose

CAS No.56038-13-2
Chemical Name:Sucralose
CBNumber:CB9363034
Molecular Formula:C12H19Cl3O8
Formula Weight:397.63
MOL File:56038-13-2.mol

Sucralose Property

Melting point 115-1018°C
Boiling point 104-107 C
alpha D +68.2° (c = 1.1 in ethanol)
Density 1.375 g/cm
vapor pressure 0Pa at 25℃
refractive index 1.604
storage temp. 2-8°C
form Powder
pka 12.52±0.70(Predicted)
color White
PH 6-8 (100g/l, H2O, 20°C)
Odor wh. cryst. powd., odorless, sweet taste
optical activity [α]/D 86.0±2.0°, c = 1 in H2O
Water Solubility Soluble in Water.
Merck 14,8880
BRN 3654410
Stability Hygroscopic
LogP -0.51 at 20℃
CAS DataBase Reference 56038-13-2(CAS DataBase Reference)
FDA 21 CFR 172.831; 101.80
Substances Added to Food (formerly EAFUS) SUCRALOSE
EWG's Food Scores 1
FDA UNII 96K6UQ3ZD4
EPA Substance Registry System .alpha.-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl 4-chloro-4-deoxy- (56038-13-2)
UNSPSC Code 85151701
NACRES NA.25

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-37/39-24/25
WGK Germany :3
RTECS :LW5440140
HS Code :2932 14 00
Hazardous Substances Data :56038-13-2(Hazardous Substances Data)
Toxicity :LD50 orally in Rabbit: > 10000 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

Sucralose Price More Price(6)

Brand: Sigma-Aldrich(India)
Product number: PHR1342
Product name : Sucralose
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500MG
Price: ₹8919.8
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 90984
Product name : Sucralose
Purity: analytical standard
Packaging: 100MG
Price: ₹13780.23
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 69293
Product name : Sucralose
Purity: ≥98.0% (HPLC)
Packaging: 100G
Price: ₹15956.05
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: S0839
Product name : Sucralose
Purity:
Packaging: 5G
Price: ₹2900
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: S0839
Product name : Sucralose
Purity:
Packaging: 25G
Price: ₹4200
Updated: 2022/05/26
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Sucralose Chemical Properties,Usage,Production

Description Sucralose is the only non-caloric sweetener made from sugar. It is in fact the latest non nutritive sweetener to have been approved by US FDA and other regulatory bodies and have hit the markets .
Sucralose is derived from sugar through a multi-step patented manufacturing process that selectively substitutes three atoms of chlorine for three hydroxyl groups on the sugar molecule. This change produces a sweetener that has no calories, yet is 600 times sweeter than sucrose, making it roughly twice as sweet as saccharin and four times as sweet as aspartame.
Chemical Properties Sucralose is a white to off-white colored, free-flowing, crystalline powder.
History Sucralose, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl- 4-chloro-4-deoxy-α-D-galactopyranoside, is a trichloro-galactosucrose sweetener developed by the British sugar company Tate & Lyle during the 1970s (U.S. Pat. 4,343,934 (Aug. 10, 1982), M. R. Jenner and D. Waite (to Talres Development), (U.S. Pat. 4,362,869 (Dec. 7, 1982), M. R. Jenner and co-workers (to Talres Development), and (U.S. Pat. 4,435,440 (Mar. 6, 1984), L. Hough, S. P. Phadnis, and R. A. Khan (to Tate & Lyle). It was licensed to McNeil-PPC, Inc., a Johnson & Johnson subsidiary, in the United States until a new agreement took place in February, 2004. McNeil Nutritionals retained ownership of SPLENDA Brand and the right for its worldwide retail and food service business. Tate & Lyle became the sole manufacturer of SPLENDA Brand sucralose and owned the right for its worldwide ingredient sales.
Uses High intensity sweetener manufactured by replacing three hydroxyl groups on the sucrose molecule with three chlorine atoms. The results are a sweetener of 0 cal that is not digested. It is 600 times as sweet as sugar with a similar flavor profile. It is heat stable, readily soluble, and maintains its stability at elevated temperatures. It has been approved for use in specific categories that include baked products, beverages, confectioneries, and certain desserts and toppings.
Uses antiprotozoal
Uses Sucralose (1,6-dichloro-1,6-dideoxy-p-fructofuranosyl-4-chloro-oc- D-galactopyra- noside) is a nonnutritive sweetener based on sucrose. It is selectively chlorinated and the glycoside link between the two rings is resistant to hydrolysis by acid or enzymes, so it is not metabolized. It has 400 to 800 times the sweetness of sucrose, is very soluble in water, and is stable in heat. It can be used in food products that are baked or fried.
Sucralose is produced by the selective chlorination of the sucrose molecule using a patented process by Tate and LyIe that replaces the three hydroxyl groups (OH) with three chlorine (Cl) atoms.
This modified sugar is minimally absorbed by the body and passes out unchanged. It was approved for use in foods and beverages in 1999 in the United States.
Uses A low-calorie artificial sweetener
Definition ChEBI: A disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond.
Production Methods Sucralose may be prepared by a variety of methods that involve the selective substitution of three sucrose hydroxyl groups by chlorine. Sucralose can also be synthesized by the reaction of sucrose (or an acetate) with thionyl chloride.
General Description Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Sucralose is a polar, chlorinated sugar synthesized from saccharose precursor. It is widely used as a sweetener in a number of food and beverage products.
Pharmaceutical Applications Sucralose is used as a sweetening agent in beverages, foods, and pharmaceutical applications. It has a sweetening power approximately 300–1000 times that of sucrose and has no aftertaste. It has no nutritional value, is noncariogenic, does not promote dental caries, and produces no glycemic response.
Biochem/physiol Actions A synthetic sweet tastant detectable by humans. Activates T1R2/T1R3 sweet taste receptors on enteroendocrine cells and elicits increased hormonal secretion of glucagon-like peptide-1 and glucose-dependent insulinotrophic peptide.
Safety Sucralose is generally regarded as a nontoxic and nonirritant material and is approved, in a number of countries, for use in food products. Following oral consumption, sucralose is mainly unabsorbed and is excreted in the feces.
The WHO has set an acceptable daily intake for sucralose of up to 15 mg/kg body-weight.
LD50 (mouse, oral): > 16 g/kg
LD50 (rat, oral): > 10 g/kg
storage Sucralose is a relatively stable material. In aqueous solution, at highly acidic conditions (pH < 3), and at high temperatures (≤35℃), it is hydrolyzed to a limited extent, producing 4-chloro-4- deoxygalactose and 1,6-dichloro-1,6-dideoxyfructose. In food products, sucralose remains stable throughout extended storage periods, even at low pH. However, it is most stable at pH 5–6.
Sucralose should be stored in a well-closed container in a cool, dry place, at a temperature not exceeding 21℃. Sucralose, when heated at elevated temperatures, may break down with the release of carbon dioxide, carbon monoxide, and minor amounts of hydrogen chloride.
Regulatory Status The FDA, in April 1998, approved sucralose for use as a tabletop sweetener and as an additive in a variety of food products. In the UK, sucralose was fully authorized for use in food products in 2005. It is also accepted for use in many other countries worldwide. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.