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Histrelin

Histrelin Structure
Histrelin
  • CAS No.76712-82-8
  • Chemical Name:Histrelin
  • CBNumber:CB8480046
  • Molecular Formula:C66H86N18O12
  • Formula Weight:1323.53
  • MOL File:76712-82-8.mol
Histrelin Property
  • alpha D20 -33.9° (c = 1 in acetic acid)
  • Density 1.46±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
  • form powder
  • pka 9.82±0.15(Predicted)
  • Stability Hygroscopic
  • NCI Dictionary of Cancer Terms histrelin acetate
  • FDA UNII H50H3S3W74
  • NCI Drug Dictionary histrelin acetate
  • ATC code L02AE05
  • Proposition 65 List Histrelin Acetate
  • UNSPSC Code 12352209
  • NACRES NA.32
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H360
  • Precautionary statements P201-P308+P313
Histrelin Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: L2761
  • Product name : [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide
  • Purity: ≥97% (HPLC), powder
  • Packaging: 0.5MG
  • Price: ₹13985.9
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: L2761
  • Product name : [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide
  • Purity: ≥97% (HPLC), powder
  • Packaging: 1MG
  • Price: ₹23317.05
  • Updated: 2022/06/14
  • Buy: Buy

Histrelin Chemical Properties,Usage,Production

  • Description Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.
  • Originator Johnson & Johnson (U.S.A.)
  • Uses [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide has been used:
    • for inducing Batrachoseps gravid females to oviposit
    • for comparing the effect of LHRH (luteinizing hormone-releasing hormone) agonists and dopamine antagonists in Lithobates pipiens
    • for inducing oviposition in females of Taricha granulosa and Ensatina eschscoltzii
    • to induce spawning in Spea hammondii adults
  • Uses LHRH agonist.
  • Definition ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
  • brand name Supprelin (Roberts Pharmaceutical).
  • Biochem/physiol Actions Glp-His-Trp-Ser-Tyr-His(Bzl)-Leu-Arg-Pro-NHEt ([des-Gly10, D-His(Bzl)6]-LH-RH) is a GnRH (gonadotropin-releasing hormone) agonist, histerelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Histerelin is used for the treatment of central precocious puberty in children. It inhibits actions of sex steroids on the male and female reproductive organs.
Histrelin Preparation Products And Raw materials
Raw materials
Preparation Products
Histrelin Suppliers
Global(148)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29857
  • Advantage：58
  • Supplier：
    Cellmano Biotech Limited
  • Tel：0551-65326643<br/>18156095617
  • Email：info@cellmano.com
  • Country：China
  • ProdList：995
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32239
  • Advantage：58
Histrelin Spectrum
76712-82-8, HistrelinRelated Search:
  • Peptide
  • hormones
  • 化学试剂
  • 药物肽
  • 药物多肽
  • 日用化学品
  • 原料
  • 医药原料
  • 医药原料药 科研原料
  • 原料药
  • 兽用多肽
  • 医用原料
  • 医药原料药
  • 多肽
  • 药物
  • 其它药物
  • 蛋白质/多肽
  • LH-RH
  • Releasing Factors
  • Peptides
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • C66H86N18O12
  • HISTRELIN ACETATE 醋酸组氨瑞林
  • 醋酸组氨瑞林/组氨瑞林
  • 5-氧代-L-脯氨酰-L-组氨酰-L-色氨酰-L-丝氨酰-L-酪氨酰-N^<T>^-苄基-D-组氨酰-L-亮氨酰-L-精氨酰-N-乙基-L-脯胺
  • 醋酸组胺瑞林
  • 组胺瑞林
  • 醋酸组氨瑞林 HISTRELINACETATE
  • 醋酸组氨瑞林
  • 组氨瑞林
  • 76712-82-8
  • [des-Gly<sup>10</sup>, <sc>D</sc>-His(Bzl)<sup>6</sup>]-LH-RH ethylamide
  • Amyridine
  • N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazoly
  • histrelin acetate
  • PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET
  • 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-
  • Histrelin Acetate(net)
  • Histrelin USP/EP/BP
  • [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
  • [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN)
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH
  • (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
  • DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH
  • (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
  • HISTRELIN
  • (HIS(BZL)6)-HISTRELIN
  • PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET
  • PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET
  • orf17070
  • 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig

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