ChemicalBook > CAS DataBase List > TERRESTRIN A

TERRESTRIN A

TERRESTRIN A Structure
TERRESTRIN A
  • CAS No.858134-23-3
  • Chemical Name:TERRESTRIN A
  • CBNumber:CB72456370
  • Molecular Formula:C34H26O8
  • Formula Weight:562.57
  • MOL File:858134-23-3.mol
TERRESTRIN A Property
  • Melting point 220-223 °C
  • Boiling point 846.9±65.0 °C(Predicted)
  • Density 1.370±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO
  • form crystalline solid
  • pka 7.81±0.15(Predicted)
  • color Off-white to light brown
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

TERRESTRIN A Chemical Properties,Usage,Production

  • Uses Vialinin A is a Potent Inhibitor of TNF-α production. Vialinin A is a potent antioxidant.
  • Biological Activity vialinin a is a potent inhibitor of ubiquitin-specific peptidases with ic50 values of 1.5, 5.9 and 22.3 μm for ubiquitin-specific peptidase 4 (usp4), usp5/isopeptidase t (isot) and uch-l1 deubiquitinating enzyme (dub), respectively [1].ubiquitin-specific peptidases (usps) are a series of proteases that deubiquitinate target proteins. the dynamic modification of a protein with ubiquitin can modify its function, localization and fate in the cell. ubiquitin hydrolase plays an important role in immunology and infection [2].in rbl-2h3 cells, vialinin a inhibited tnf-ɑ production and release and inhibited usp5 enzymatic activity. in usp5 sirna-knockdown rbl-2h3 cells, vialinin a inhibited tnf-ɑ production and release in a dose dependent way. also, the mrna expression of tnf-ɑ was decreased significantly [2]. in rbl-2h3 cells, vialinin a inhibited tnf-ɑ production with ic50 value of 0.09 nm. also, it inhibited the release of interleukin 4, β-hexosaminidase and monocyte chemotactic protein 1, which suggested vialinin a had anti-allergic activities [3].
  • References [1]. okada k, ye yq, taniguchi k, et al. vialinin a is a ubiquitin-specific peptidase inhibitor. bioorg med chem lett, 2013, 23(15): 4328-4331.
    [2]. yoshioka y, ye yq, okada k, et al. ubiquitin-specific peptidase 5, a target molecule of vialinin a, is a key molecule of tnf-α production in rbl-2h3 cells. plos one, 2013, 8(12): e80931.
    [3]. onose j, xie c, ye yq, et al. vialinin a, a novel potent inhibitor of tnf-alpha production from rbl-2h3 cells. biol pharm bull, 2008, 31(5): 831-833.
TERRESTRIN A Preparation Products And Raw materials
Raw materials
Preparation Products
TERRESTRIN A Suppliers
Global(24)Suppliers
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：57505
  • Advantage：58
  • Supplier： EMMX Biotechnology LLC
  • Tel：888-539-0666
  • Email：info@emmx.com
  • Country：United States
  • ProdList：8447
  • Advantage：60
  • Supplier： TargetMol Chemicals Inc.
  • Tel： 4008200310
  • Email：marketing@tsbiochem.com
  • Country：China
  • ProdList：24683
  • Advantage：58
TERRESTRIN A Spectrum
858134-23-3, TERRESTRIN ARelated Search:
  • 抑制剂
  • 天然产物
  • 中药对照品
  • 化合物VIALININ A
  • 858134-23-3
  • Benzeneacetic acid, 1,1'-(4,4'',5',6'-tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) ester
  • NOJUKCRPSUMHQQ-UHFFFAOYSA-N
  • 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester
  • VIALININ A
  • TERRESTRIN A

Home

My