2-AMINO-5-BROMO-3-FLUORO-BENZONITRILE

Synthesis

Take 2-amino-5-fluorobenzoic acid as raw material, through bromination, diazotization, reduction synthesis of intermediate 3-bromo-5-fluorobenzoic acid, then toluene as a solvent, chlorosulfoxide chlorination after the passage of ammonia, the result of the amide and phosphorus pentoxide coheated distillation can be obtained 2-amino-5-bromo-3-fluorobenzonitrile, the total yield of 53.4% (as 2-amino-5-fluorobenzoic acid).