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Swertisin

Swertisin Structure
Swertisin
  • CAS No.6991-10-2
  • Chemical Name:Swertisin
  • CBNumber:CB5724709
  • Molecular Formula:C22H22O10
  • Formula Weight:446.4
  • MOL File:6991-10-2.mol
Swertisin Property
  • Melting point 245-246℃
  • Boiling point 716.6±60.0 °C(Predicted)
  • Density 1.583±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO; sparingly soluble in methanol;
  • pka 5.76±0.40(Predicted)
  • form powder
  • color White-pale yellow
  • Water Solubility slightly soluble in water
  • UNSPSC Code 41116107
  • NACRES NA.24
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Swertisin Chemical Properties,Usage,Production

  • Chemical Properties Swertisin is a flavonoid compound that appears as a light yellow powder or crystalline powder at room temperature. Its chemical formula is C22H22O10, with a molecular weight of 446. it is soluble in organic solvents such as methanol and dimethyl sulfoxide. It has antioxidant,anti-diabetic, anti-depressant, anti-inflammatory, anti-viral, and anti-radiation pharmacological effects.
  • Uses food and beverages
  • Definition ChEBI: Swertisin is a flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue. It has a role as a plant metabolite, an adenosine A1 receptor antagonist, an anti-inflammatory agent, an antioxidant and a hypoglycemic agent. It is a flavone C-glycoside, a monosaccharide derivative, a polyphenol, a monomethoxyflavone and a dihydroxyflavone. It is functionally related to an apigenin.
  • Biological Activity Swertisin is a flavonoid C-glycoside that has been found in Swertia japonica and has diverse biological activities. It inhibits sodium-glucose cotransporter 2 (SGLT2) in HEK293 cells when used at a concentration of 7.5 μg/ml and is an adenosine A1 receptor antagonist (IC50 = 137 μM). Swertisin (0.2-5 μM) inhibits hepatitis B virus (HBV) replication in HepG2 2.2.15 cells. It decreases blood glucose levels in a mouse model of diabetes induced by streptozotocin (Item No. 13104), as well as prevents scopolamine-induced increases in escape latency in the Morris water maze in mice.
  • in vivo

    Swertisin (30 mg/kg, orally, single dose) helps improve symptoms of schizophrenia in mice, including sensory motor gating disruptions and cognitive impairments[1].
    Swertisin (2.5 mg/kg, intraperitoneally, once daily, days) reduces the expression of SGLT2 in mouse kidney tissue and can quickly lower blood sugar[2].
    Swertisin (0-10 mg/kg, intraperitoneally, every other day, 20 days) significantly inhibits HBV replication in a HBV transgenic mouse model[3].

    Animal Model:Mice induced by MK801 (HY-15084B)[1]
    Dosage:30 mg/kg; single dose
    Administration:Oral gavage (p.o.)
    Result:Alleviated the pre-pulse inhibition defect, reversed memory recognition impairment, and the elevated phosphorylation levels of Akt and GSK-3β signaling molecules in the prefrontal cortex restore normal function.
    Animal Model:BALB/c mice induced by STZ (HY-13753)[2]
    Dosage:2.5 mg/kg; daily; 15 days
    Administration:Intraperitoneal injection (i.p.)
    Result:Improved overall glucose homeostasis, reduced SGLT2 expression in renal tissue, reduced PKC expression, and had a rapid hypoglycemic effect.
    Animal Model:HBV transgenic mice[3]
    Dosage:0, 5, 10 mg/kg; every other day; 20 days
    Administration:Intraperitoneal injection (i.p.)
    Result:Showed that there was no significant weight loss, no significant changes in serum ALT and AST levels, and reduced serum HBsAg and HBeAg levels.
  • IC 50 SGLT2
  • References [1] GURPRIT BHARDWAJ . Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy[J]. Archives of biochemistry and biophysics, 2021, 710: Article 108995. DOI:10.1016/j.abb.2021.108995.
    [2] K. PATEL D. P. Biological importance and therapeutic benefit of swertisin: An overview of medicinal importance and pharmacological activities[J]. Current Bioactive Compounds, 2022. DOI:10.2174/1573407218666220801113334.
    [3] HONG-YAN XU . Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim[J]. Journal of ethnopharmacology, 2020, 257: Article 112787. DOI:10.1016/j.jep.2020.112787.
Swertisin Preparation Products And Raw materials
Raw materials
Preparation Products
Swertisin Suppliers
Global(121)Suppliers
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Swertisin Spectrum
6991-10-2, SwertisinRelated Search:
  • Tetra-substituted Flavones
  • 抑制剂
  • 试剂
  • 标准品，对照品
  • 标准品 -中药标准品
  • 对照品
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  • 1859726
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  • 当药黄素,10 MM DMSO 溶液
  • 标准品对照品】SWERTISIN
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  • 磷酸三(1
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  • 当药黄素, 来源于当药
  • 芫花素 6-C-葡糖苷
  • 当药黄素
  • 6991-10-2
  • Swertisin, 10 mM in DMSO
  • Swertisin-RM
  • Tris(1
  • 3-dichloroisopropyl)phosphate
  • 4H-1-Benzopyran-4-one, 6-β-D-glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
  • Swertia flavin
  • Swertisin, 98%, from Swertia diluta (Turcz.) Benth. & Hook.f.
  • Genkwanin 6-C-Glucoside
  • SWERTISIN(P)
  • 6-(β-D-Glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
  • 4',5-Dihydroxy-7-methoxy-6-β-D-glucopyranosylflavone
  • APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER
  • SWERTISIN

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