Synthesis
General procedure for the synthesis of 1-(3,5-dichlorophenyl)ethanone from 3,5-dichloroiodobenzene (37.0 g, 136 mmol) and acetic anhydride: 3,5-dichloroiodobenzene, Pd2(dba)3 (1.5 g, 1.6 mmol), and lithium chloride (29.0 g, 682 mmol) were dissolved in 100 ml of DMF in a 500 ml round bottomed flask. Subsequently 64.0 ml of acetic anhydride and 47.0 ml of N-ethyl diisopropylamine were added to the reaction mixture. The reaction mixture was heated at 100°C for the reaction. After completion of the reaction, water was added to the mixture, extracted with ethyl acetate and the product was purified by column chromatography using ethyl acetate as eluent. 8 g of 1-(3,5-dichlorophenyl)ethanone was finally obtained.
