ChemicalBook > CAS DataBase List > 2',4',6'-Trihydroxyacetophenone monohydrate

2',4',6'-Trihydroxyacetophenone monohydrate

CAS No.480-66-0
Chemical Name:2',4',6'-Trihydroxyacetophenone monohydrate
CBNumber:CB2333652
Molecular Formula:C8H8O4
Formula Weight:168.15
MOL File:480-66-0.mol

2',4',6'-Trihydroxyacetophenone monohydrate Property

Melting point 219-221 °C(lit.)
Boiling point 257.07°C (rough estimate)
Density 1.3037 (rough estimate)
refractive index 1.5090 (estimate)
storage temp. Store below +30°C.
solubility DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly), Water (Very Slightly,
pka 7.76±0.23(Predicted)
form Powder
color light yellow
Water Solubility Soluble in water.
BRN 1911197
Stability Stable under recommended storage conditions., Stable Under Recommended Storage C
LogP 1.472 (est)
CAS DataBase Reference 480-66-0(CAS DataBase Reference)
FDA UNII 8L7XD8830T
NIST Chemistry Reference Ethanone, 1-(2,4,6-trihydroxyphenyl)-(480-66-0)
EPA Substance Registry System Ethanone, 1-(2,4,6-trihydroxyphenyl)- (480-66-0)
UNSPSC Code 12352115

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36-24/25
WGK Germany :3
RTECS :AN0528000
TSCA :Yes
HazardClass :IRRITANT
HS Code :29145000

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H303-H315-H319-H335
Precautionary statements P280g-P261-P305+P351+P338

2',4',6'-Trihydroxyacetophenone monohydrate Price More Price(4)

Brand: ALFA India
Product number: ALF-L04156-14
Product name : 2',4',6'-Trihydroxyacetophenone hydrate, 98+%
Purity:
Packaging: 25g
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Brand: ALFA India
Product number: ALF-L04156-06
Product name : 2',4',6'-Trihydroxyacetophenone hydrate, 98+%
Purity:
Packaging: 5g
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Brand: TCI Chemicals (India)
Product number: T1888
Product name : 2',4',6'-Trihydroxyacetophenone Monohydrate
Purity: min. 98.0 %
Packaging: 5G
Price: ₹3800
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: T1888
Product name : 2',4',6'-Trihydroxyacetophenone Monohydrate
Purity: min. 98.0 %
Packaging: 25G
Price: ₹13400
Updated: 2022/05/26
Buy: Buy

2',4',6'-Trihydroxyacetophenone monohydrate Chemical Properties,Usage,Production

Chemical Properties Light Brown Solid
Uses Induced choleresis in rats is mediated through multidrug resistance protein-2 (Mrp2). It enhances bile secretion.
Uses Monoacetylphloroglucinol (MAPG) is small molecular weight phenolic metabolite belonging to the phloroglucinol (1,3,5-trihydroxybenzene) family, produced by bacteria including Pseudomonas strains. MAPG exhibits a broad range of biological activity albeit with mostly low potency. In the search for novel actives, MAPG and related metabolites are important metabolites for dereplication to eliminate leads due to high amounts of weakly potent actives. Although weakly active, this family appears to be important in the biocontrol of plant diseases by some Pseudomonas strains.
Preparation Preparation by reaction of acetic anhydride on phloroglucinol,
with concentrated sulfuric acid at 130° (70%)
with boron trifluoride at 10° (62.5–68%)
with zinc chloride at 145–150° (50%)
with Amberlite IR-120 or Zeokarb 225 (cation exchange resins, sulfonic acid type) at 160° (39%).
Definition ChEBI: A benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acid c glycans and glycopeptides.
Biological Activity monoacetylphloroglucinol (mapg), small molecular weight phenolic metabolite, is produced via bacteria including pseudomonas strains. mapg is acetylated to form the broad-spectrum antibiotic, 2,4-diacetylphloroglucinol (dapg) by mapg acetyltransferase. in addition, mapg exerts fairly weak potency when exhibiting a broad range of antibiotic activity. even though weakly active, it seems that mapg is essential in the biocontrol of plant diseases by some pseudomonas strains [1].
target HMG-CoA Reductase
Purification Methods Crystallise the ketone from hot H2O (35mL/g). [Beilstein 8 IV 2729.]
References [1]. hayashi, a., saitou, h., mori, t., matano, i., sugisaki, h., & maruyama, k. molecular and catalytic properties of monoacetylphloroglucinol acetyltransferase frompseudomonassp. ygj3. bioscience, biotechnology, and biochemistry. 2012; 76(3): 559-566.