Description
Maduramycin ammonium salt is a white crystalline powder with a melting point of 165-167°C. It is insoluble in water and soluble in organic solvents. Because of its broad anticoccidial spectrum and not easy to develop drug resistance, it is widely used. The dosage is very small. At present, our country stipulates that the amount of maduramycin ammonium salt added to the feed for preventing chicken coccidiosis is 5mg/kg.
Chemical Properties
White Solid
Uses
Polyether antibiotic chemically related to the lonomycins. Coccidiostat
Uses
Maduramicin ammonium is prepared from maduramicin by taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in ammonium hydroxide solutions. The ammonium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Maduramicin is also active against Treponema and Cryptosporidium. Maduramicin is an ionophore, forming complexes with monovalent cations, with a higher affinity for K+ than Na+.
Uses
Maduramcin ammonium is prepared from maduramicin by taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in ammonium hydroxide solutions. The ammonium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Maduramicin is also active against Treponema and Cryptosporidium. Maduramicin is an ionophore, forming complexes with monovalent cations, with a higher affinity for K+ than Na+.
Definition
ChEBI: Maduramicin is a glycoside.
