Isovaleramide (100 mg/kg, p.o., a single dose at 4-hour following fasting) evidences a 90% index protection against the maximal electroshock seizure in mice[1].
Isovaleramide (10 and 20 mg/kg, i.v.,every 12 h for 48 h) reduces the mortality rate, attenuates the pathological damage of kidney tissues in EG-poisoned rats and down-regulates the expression of serum biomarkers of AKI[2].
Isovaleramide (100 mg/kg; p.o.) shows a 90% index protection against the maximal electroshock (MES)-induced seizure in mice, comparable to Sodium phenytoin (HY-B0448A)[4].
| Animal Model: | ICR mice with electric shock induced seizures[1] |
| Dosage: | 100 mg/kg |
| Administration: | p.o., a single dose at 4-hour following fasting |
| Result: | Evidenced a 90% index protection against the maximal electroshock seizure in mice. |
| Animal Model: | Rat model of EG poisoning[1] |
| Dosage: | 10 and 20 mg/kg |
| Administration: | i.v.,every 12 h for 48 h |
| Result: | Effectively reduced the mortality of EG-poisoned rats, and this effect may be dose-dependent. |
