Description
Fotemustine is a new nitrosourea reportedly effective in the treatment of disseminated
malignant melanoma, with only mild hematological toxicity. Response rate is generally
lower in patients with colonic, breast, head and neck cancer.
Originator
Servier (France)
Uses
Fotemustine is used in patients malignant gliomas to improve the efficacy of radiotherapy. Used in the treatment of glioblastomas.
Definition
ChEBI: Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate is a member of the class of N-nitrosoureas that is ethyl diethylphosphonate in the hydrogen at position 1 of the ethyl group attached to the phosphorus has been replaced by a [(2-chloroethyl)(nitroso)carbamoyl]amino group. It is an organic phosphonate, a member of N-nitrosoureas and an organochlorine compound.
