C22 Galactosylceramide (d18:1/22:0)

Definition

ChEBI: 1-(beta-D-galactosyl)-N-behenoylsphingosine is a D-galactosyl-N-acylsphingosine where the ceramide N-acyl group is docosananoyl and the D-galactosyl component has beta anomeric configuration. It has a role as a mouse metabolite. It is functionally related to a docosanoic acid.

Biological Activity

C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2 C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricted diet.1 C22 Galactosylceramide has been found in postmortem hippocampus from patients with Alzheimer's disease.2 [Matreya, LLC.]

References

1.Jové, M., Ayala, V., Ramírez-Nú?ez, O., et al.Specific lipidome signatures in central nervous system from methionine-restricted miceJ. Proteome Res.12(6)2679-2689(2013) 2.Hejazi, L., Wong, J.W.H., Cheng, D., et al.Mass and relative elution time profiling: Two-dimensional analysis of sphingolipids in Alzheimer's disease brainsBiochem. J.438(1)165-175(2011)