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Econazole

Econazole Structure
Econazole
  • CAS No.27220-47-9
  • Chemical Name:Econazole
  • CBNumber:CB9447792
  • Molecular Formula:C18H15Cl3N2O
  • Formula Weight:381.68
  • MOL File:27220-47-9.mol
Econazole Property
  • Melting point: :86.8°C
  • Boiling point: :533.8±50.0 °C(Predicted)
  • Density  :1.33±0.1 g/cm3(Predicted)
  • storage temp.  :Sealed in dry,Room Temperature
  • solubility  :Practically insoluble in water, very soluble in ethanol (96 per cent) and in methylene chloride.
  • form  :neat
  • pka :6.68±0.12(Predicted)
  • Water Solubility  :0.37g/L(ambient temperature)
  • CAS DataBase Reference :27220-47-9(CAS DataBase Reference)
  • FDA UNII :6Z1Y2V4A7M
  • EPA Substance Registry System :Econazole (27220-47-9)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Econazole Price More Price(2)
  • Brand: Sigma-Aldrich
  • Product number: Y0001236
  • Product name : Econazole
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: y0001236
  • Price: $190
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: Y0001236
  • Product name : Econazole
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/03/22
  • Buy: Buy

Econazole Chemical Properties,Usage,Production

  • Chemical Properties White or almost white powder
  • Originator Pevaryl,Cilag Chemie,France,1976
  • Uses antineoplastic, anti-estrogen.
    Econazole (Spectazole) is a synthetic imidazole. Econazole blocks C-14 demethylation of sterols, interfering with the biosynthesis of ergosterol, which results in disorganization of the fungal plasma cell membrane and increased permeability. It is active against dermatophytes, yeast, P. orbiculare, Aspergillus, Cladosporium, and Sporothrix.
  • Indications Econazole (Spectazole) is a synthetic imidazole. Econazole blocks C-14 demethylation of sterols, interfering with the biosynthesis of ergosterol, which results in disorganization of the fungal plasma cell membrane and increased permeability. It is active against dermatophytes, yeast, P. orbiculare, Aspergillus, Cladosporium, and Sporothrix.
  • Manufacturing Process A suspension of 10.3 parts of α-(2,4-dichlorophenyl)-imidazole-1-ethanol and 2.1 parts of sodium hydride in 50 parts of dry tetrahydrofuran is stirred andrefluxed for 2 hours. After this reaction-time, the evolution of hydrogen is ceased. Then there are added successively 60 parts dimethylformamide and 8 parts of p-chlorobenzylchloride and stirring and refluxing is continued for another two hours. The tetrahydrofuran is removed at atmospheric pressure. The dimethylformamide solution is poured onto water. The product, 1-[2,4- dichloro-β-(p-chlorobenzyloxy)phenethyl]imidazole, is extracted with benzene. The extract is washed with water, dried, filtered and evaporated in vacuo. From the residual oily free base, the nitrate salt is prepared in the usual manner in 2-propanol by treatment with concentrated nitric acid, yielding, after recrystallization of the crude solid salt from a mixture of 2-propanol, methanol and diisopropylether, 1-[2,4-dichloro-β-(pchlorobenzyloxy)phenethyl]imidazole nitrate; MP 162°C.
  • brand name Spectazole (Johnson & Johnson).
  • Therapeutic Function Antifungal
  • Chemical Synthesis Econazole, 1-[2,4-dichloro-β-[(4-chlorobenzyl)oxy]phenethyl]-imidazole (35.2.8), is an analog of myconazole. It differs in the presence of a single chlorine atom in the benzyl part of the molecule, and it is synthesized in the same manner, except that it uses 4-chlorobenzylchloride in the last stage instead of 2,4-dichlorobenzylbromide.
Econazole Preparation Products And Raw materials
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27220-47-9, EconazoleRelated Search:
  • 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazol
  • 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)-imidazol
  • 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole
  • ECONAZOLE
  • ECONAZOLUM
  • 1-[2,4-Dichloro-β-[(p-chlorobenzyl)oxy]phenethyl]imidazole
  • 1H-Imidazole, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-
  • Imidazole, 1-[2,4-dichloro-β-[(p-chlorobenzyl)oxy]phenethyl]- (8CI)
  • NSC 187789
  • Econazole (base and/or unspecified salts)
  • 1-(1H-Imidazole-1-yl)-2-(2,4-dichlorophenyl)-2-(4-chlorobenzyloxy)ethane
  • 1-[2,4-Dichloro-β-(p-chlorobenzyloxy)phenethyl]-1H-imidazole
  • 1-[β-[(4-Chlorobenzyl)oxy]-2,4-dichlorophenethyl]-1H-imidazole
  • 1-(2-((4-Chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
  • econazole:1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1h-IMIDAZOLE
  • 1-(2,4-Dichloro-B-((P-Chlorobenzyl)Oxy)Phenethyl)Imidazole
  • Econazole Solution, 100ppm
  • Miconazole Nitrate EP Impurity B
  • (±)-Econazol
  • Econazole CRS
  • Econazole USP/EP/BP
  • 27220-47-9
  • C18H15Cl3N2O
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