Description
BRD 7116 (329059-55-4) inhibits leukemia stem cell (LSC) activity (EC50 = 200 nM). Displays a >100-fold selectivity for LSCs over normal hematopoietic stem cells.1
Uses
BRD 7116 inhibits LSCe (leukemia stem cell) and HSPCs (Hematopoietic stem cells ), by displaying cell-non-autonomous anti-leukemia activity.
Definition
ChEBI: 2,2,3,3-tetramethyl-N-[4-[4-[[oxo-(2,2,3,3-tetramethylcyclopropyl)methyl]amino]phenyl]sulfonylphenyl]-1-cyclopropanecarboxamide is an anilide.
References
1) Hartwell et al. (2013), Niche-based screening identifies small-molecule inhibitors of leukemia stem cells; Nat. Chem. Biol., 9 840