ChemicalBook CAS DataBase List K145

K145

Product NameK145
CAS1309444-75-4
CBNumberCB92677052
MFC18H24N2O3S
MW348.46
MDL NumberMFCD28167726
MOL File1309444-75-4.mol

Chemical Properties

storage temp.	2-8°C
solubility	Soluble in DMSO
form	Powder
color	off-white
UNSPSC Code	12352200
NACRES	NA.77

K145 Price

Product number	Packaging	Price	Product description	Buy
ApexBio Technology B1298	5mg	$104	K145	Buy
ApexBio Technology B1298	10mg	$173	K145	Buy
ApexBio Technology B1298	50mg	$623	K145	Buy
ApexBio Technology B1298	100mg	$1118	K145	Buy
Crysdot CD31003934	5mg	$46	K145 98+%	Buy

K145 Chemical Properties,Usage,Production

Biological Activity

K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with IC50 of 4.3 μM and Ki of 6.4 μM.It is inactive against SphK1 and other protein kinases,it induces apoptosis and has potent antitumor activity.

in vitro

K145 (0-10 μM; 24-72 hours; U937 cells) treatment significantly inhibits the growth of U937 cells in a concentration-dependent manner.
K145 (10 μM; 24 hours; U937 cells) ) treatment significantly induces apoptosis in U937 cells.
K145 (4-8 μM; 3 hours; U937 cells) treatment decreases the phosphorylation of ERK and Akt.
Treatment with K145 (10 μM) causes a decrease of total cellular S1P without significant effects on ceramide levels.

Cell Viability Assay

< td class="col2"> U937 cells td>

Cell Line:
Concentration:	0 μM, 4 μM, 6 μM , 8 μM, 10 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Significantly inhibited the growth of U937 cells in a concentration-dependent manner.

Apoptosis Analysis

Cell Line:	U937 cells
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Significantly induced apoptosis in U937 cells.

Western Blot Analysis < /p>

Cell Line:	U937 cells
Concentration:	4 μM, 8 μM
Incubation Time: < /td>	3 hours
Result:	Phosphorylated ERK and Akt wer e decreased.

in vivo

K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice.

Animal Model:	BALB/c-nu mice injected with U937 cells
Dosage:	50 mg/kg
Administration:	Oral gavage; daily; for 15 days
Result:	Oral gavage; daily; for 15 daysInhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed.

target

IC50: 4.3 μM (SphK2)
Ki: 6.4 μM (SphK2)

Preparation Products And Raw materials

K145 Supplier

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19881	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3466	58
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2384	58
SPIRO PHARMA		eric_feng1954@126.com	China	9248	55

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