Description
This purine base is produced by Agarius nebularis Batsch. (Syn. Clitocybe
nebularis). It is laevorotatory with [α]
25D - 48.6° (c 1.0, H20).
Chemical Properties
Crystalline Solid
Uses
Nebularine is shown to have inhibitory effects against mouse Sarcoma 180 and mycobacteria.
Definition
ChEBI: A purine ribonucleoside that is 9H-purine attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage.
Purification Methods
Nebularine is recrystallised from butanone/MeOH or EtOH and forms a MeOH photo-adduct. It is a strong inhibitor of adenosine deaminase [EC 3.5.4.4]. [Nair & Weichert Bioorg Chem 9 423 1980, Lfgren et al. Acta Chem Scand 7 225 1953, UV: Brown & Weliky J Biol Chem 204 1019 1953, Beilstein 26 III/IV 1740.]
