Description
Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson’s, Alzheimer’s, and prion diseases. A screen for protective activity against ER stress-
dependent cell death identified termitomycamides, extracts from the fruiting bodies of
T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites. Termitomycamide E is a fatty acid isolated from
T. titanicus that at a dose of 0.1 μg/ml protects against ER stress-
dependent cell death in Neuro2a cells induced by tunicamycin.
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References
1. Choi, J.H., Maeda, K., Nagai, K., et al.
Termitomycamides A to E, fatty acid amides isolated from the mushroom Termitomyces titanicus, suppress endoplasmic reticulum stress Org. Lett. 12(21),5012-5015(2010).
