Uses
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.
Definition
ChEBI: Tubulysin A is a diester and a carboxylic acid.
Biochem/physiol Actions
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.
in vivo
Tubulysin A (0.04 mg/kg, 0.06 mg/kg; Intraperitoneal (i.p.); once daily for 4 days) can inhibit the growth of tumor cells in mouse xenotransplantation model[1].
| Animal Model: | Mouse xenotransplantation model[1] |
| Dosage: | 0.04 and 0.06 mg/kg |
| Administration: | Intraperitoneal (i.p.) |
| Result: | Inhibited the growth of tumor cells. |
IC 50
Traditional Cytotoxic Agents
