Uses
Spongosine (2-Methoxyadenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References
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10.1016/j.drudis.2021.02.020[2] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:
10.2174/138161212801227005[3] PHILIP A. SEARLE Tadeusz F M. Isolation of Spongosine and 2’-Deoxyspongosine from a Western Australian Sponge of the Order Hadromerida (Tethyidae)[J]. Journal of Natural Products , 1994, 57 10: 1452-1454. DOI:
10.1021/np50112a018[4] ZHAN-GUO GAO. 2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors[J]. Biochemical pharmacology, 2004, 68 10: Pages 1985-1993. DOI:
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10.1080/15257779508010711[6] FREDERICK A. FUHRMAN Geraldine J F. Effects of some naturally-occurring purine ribosides on purinergic receptors in cardiac and smooth muscle[J]. Comparative biochemistry and physiology. C: Comparative pharmacology, 1982, 72 2: Pages 203-210. DOI:
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