Synthesis
General procedure for the synthesis of 2-amino-6-chlorobenzaldehyde from (2-amino-6-chlorophenyl)-methanol: Manganese dioxide (13.6 g, 157 mmol) was added to a solution of 2-amino-6-chlorophenylmethanol (2.75 g, 17.5 mmol) dissolved in 150 mL diethyl ether. The reaction mixture was stirred at room temperature for 0.5 h, followed by filtration through a diatomaceous earth pad and washed well with ethyl acetate. The filtrate was concentrated under reduced pressure to give 2.62 g (96% yield) of 2-amino-6-chlorobenzaldehyde as a pale yellow solid.
References
[1] Patent: WO2006/10142, 2006, A2. Location in patent: Page/Page column 70; 71
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 19, p. 5810 - 5831
[3] ChemistryOpen, 2015, vol. 4, # 2, p. 107 - 110
[4] Patent: US2018/105527, 2018, A1. Location in patent: Paragraph 0786-0788
[5] Organic and Biomolecular Chemistry, 2016, vol. 14, # 38, p. 8966 - 8970
