Uses
Hycanthone is the active metabolite of the anthelmintic prodrug Lucanthone (L473700), which is used in the treatment of schistosomiasis.
Definition
ChEBI: A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual
or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.
General Description
Odorless canary yellow to yellow-orange crystalline powder. Bitter taste.
Air & Water Reactions
1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE may be sensitive to prolonged exposure to air and light. Highly soluble in water.
Reactivity Profile
1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE is very sensitive to acid. .
Fire Hazard
Flash point data for 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE are not available; however, 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE is probably combustible.
Safety Profile
Poison by
subcutaneous, intravenous, and
intramuscular routes. Moderately toxic by
ingestion. Experimental teratogenic effects.
Human mutation data reported.
Questionable carcinogen with experimental
carcinogenic data. When heated to
decomposition it emits very toxic fumes of
NOx and SOx.
