Description
Diminazene is a diamidine that is cytotoxic to protozoa, including
Trypanosoma,
Babesia, and
Cytauxzoon. Diamidines, including diminazene, affect a variety of enzymes and modulate interactions between nucleic acids and proteins. Diminazene inhibits diamine oxidase with a K
i value of 13 nM. In
Trypanosoma, transport proteins are important in the effectiveness of diminazene. In rats and
in vitro, diminazene enhances the enzymatic activity of angiotensin-converting enzyme 2.
Chemical Properties
solid
Uses
An anti-protozoal and anti-trypanosomal compound
Uses
antiprotozoal as aceturate
Uses
Diminazene aceturate is an anti-protozoal drug. Diminazene Diaceturate is used as an anti-trypanosomal agent.
Definition
ChEBI: An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine.
Veterinary Drugs and Treatments
Diminazene is used to treat trypanosomiasis in dogs and livestock
(sheep, goats, cattle), Babesia infections in dogs and horses, and cytauxzoonosis
in cats. The drug is not commercially available in the
USA, but is available and used in many countries.
