Biological Activity
β-ODAP is a potent inhibitor of HIF-prolyl hydroxylase-2 (PHD-2) th at induces HIF dependent HRE (hypoxia response element) in normoxic conditions. β-ODAP is an analog of glutamic acid present in Lathyrus sativus (grass pea) th at activates AMPA receptors. β-ODAP causes neurolathyrism upon prolonged consumption of L. sativus seeds.', 'β-ODAP is considered more neurotoxic than α-ODAP, thus during food processing, its conversion to α isomer is essential. β-ODAP exhibits its neurotoxicity via the activation of metabotropic glutamatergic receptor.
