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BUCLIZINE

BUCLIZINE Structure
BUCLIZINE
  • CAS No.82-95-1
  • Chemical Name:BUCLIZINE
  • CBNumber:CB9111794
  • Molecular Formula:C28H33ClN2
  • Formula Weight:433.03
  • MOL File:82-95-1.mol
BUCLIZINE Property
  • Boiling point: :bp0.001 217-220°
  • Density  :0.9970 (rough estimate)
  • refractive index  :1.5940 (estimate)
  • EWG's Food Scores :1
  • FDA UNII :0C94V6X681
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

BUCLIZINE Chemical Properties,Usage,Production

  • Originator Longifine,UCB
  • Uses Buclizine is an antinauseant.
  • Definition ChEBI: An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups.
  • Manufacturing Process 1 mol 4-chlorobenzhydril chloride was heated in toluene to reflux with 1 mol ethyl ester of piperazine 1-carboxylic acid at about 150°C in a presence of an excess of triethyl amine. On cooling the triethyl amine hydrochloride was filtered off, a solvent was removed in vacuum and the residue [(4-chlorophenyl)- phenyl-methyl]piperazine carboxylic acid ethyl ester was boiled straight away with potassium hydroxide in ethanol for 48 hours. After removing ethanol in vacuum to dryness, the residue was dissolved in benzene and washed with water. The benzene solution was dried, benzene removed in vacuum. The residue was distilled to give 4-chlorobezhydryl-piperazine. It had given the desired 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)- piperazine, buclizine, by a reaction with 4-tert-butylbenzyl chloride in the presence of any halogen hydrochloride acceptor (triethyl amine, sodium or potassium carbonate and so on). The obtained product had BP: 230°- 240°C/0.001 mm Hg.
  • brand name Bucladin (Stuart).
  • Therapeutic Function Antihistaminic, Antiallergic, Antinauseant, Tranquilizer, Appetite stimulant
BUCLIZINE Preparation Products And Raw materials
Raw materials
Preparation Products
BUCLIZINE Suppliers
Global(44)Suppliers
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82-95-1, BUCLIZINERelated Search:
  • Histabuticine
  • Histabutizine
  • Histabutyzine
  • Hitabutyzyne
  • Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-
  • piperazine,1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)
  • Postafen
  • ah2526
  • Aphilan-R base
  • aphilan-rbase
  • Bucladin
  • Buclifen
  • 1-[4-(Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]piperrazine
  • AH 2526
  • 1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
  • 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-piperazin
  • 1-(p-tert-Butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)piperazine
  • Buclozin
  • Buclizine diHCl
  • BUCLIZINE
  • 1-(4-tert-butylbenzyl)-4-(4-chlorobenzhydryl)piperazine
  • Buclizinebase
  • Buclizine (base and/or unspecified salts)
  • 82-95-1
  • 1129-74-8
  • C28H33ClN2