Description
Alliin is a cysteine sulfoxide constituent of garlic that is converted by alliinase to allicin, which imparts its pungent aroma and flavor. Alliin exhibits anti-
cancer, anti-
microbial, anti-
hypertensive, cardioprotective, and anti-
oxidant activities. It has been shown to inhibit squalene monooxygenase, a rate-
limiting step in the downstream pathway of cholesterol biosynthesis, with an IC
50 value of 120 μM.
Uses
(±)-L-Alliin has been used in nutrient broth No. 2 (NB2) for determining the concentrations of garlic-derived products active against Clostridium jejuni.
Uses
rac-Alliin has shown notable preventive effects on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury. rac-Alliin is also known to exhibit anticancer, antimicrobial, antihypertensive, antioxidant activities.
Definition
ChEBI: 3-(Allylsulphinyl)-L-alanine is a L-alpha-amino acid.
General Description
Alliin is the precursor of allicin.
Biochem/physiol Actions
S-Allyl-L-cysteine ((±)-L-Alliin) (SAC) may be used to study its potential as an anti-Alzheimer′s factor. SAC has been shown to increase cell proliferation and neuroblast differentiation by increasing 5-HT(1A) and provide antioxidative benefit to neurons and synapses.
References
[1] TVRTKO KARLO KOVAEVI. The Interplay of Physiological and Biochemical Response to Short-Term Drought Exposure in Garlic (Allium sativum L.).[J]. Plants-Basel, 2023, 12 18. DOI:
10.3390/plants12183215[2] CHIEKO OHSUMI Konosuke S Takahisa Hayashi. Formation of alliin in the culture tissues of Allium sativum. Oxidation of S-allyl-l-cysteine[J]. Phytochemistry, 1993, 33 1: Pages 107-111. DOI:
10.1016/0031-9422(93)85404-f[3] S.M. ASDAQ M. N I. Potential of garlic and its active constituent, S-allyl cysteine, as antihypertensive and cardioprotective in presence of captopril[J]. Phytomedicine, 2010, 17 13: Pages 1016-1026. DOI:
10.1016/j.phymed.2010.07.012[4] JI-MYUNG KIM. StructureActivity Relationship of Neuroprotective and Reactive Oxygen Species Scavenging Activities for Allium Organosulfur Compounds[J]. Journal of Agricultural and Food Chemistry, 2006, 54 18: 6547-6553. DOI:
10.1021/jf060412c[5] XAVIER LIEBEN LOUIS. Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide.[J]. BMC Complementary and Alternative Medicine, 2012, 12: 140. DOI:
10.1186/1472-6882-12-140[6] RADU VASILE BAGIU Monica B Brigitha Vlaicu. Chemical composition and in vitro antifungal activity screening of the Allium ursinum L. (Liliaceae).[J]. International Journal of Molecular Sciences, 2012, 13 2: 1426-1436. DOI:
10.3390/ijms13021426
