Brodimoprim

Description

Brodimoprim, a dihydrofolate reductase inhibitor, was introduced for the treatment of common infections of upper respiratory tract such as sinusitis and exacerbation of chronic bronchitis. It has a broad spectrum of antimicrobial activities against most Gram-positive and -negative pathogens including some bacterial strains that are resistant to amoxicillin, a widely used antibiotic for the indicated infections. Brodimoprim also has a favorable pharmacokinetic profile exemplified by its long half-life and good tissue penetration.

Chemical Properties

Off-White to Pale Yellow Solid

Originator

Helsinn (Switzerland)

Uses

A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.

Definition

ChEBI: An aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group.

brand name

Hyprim;Unitrim