Uses
1-Bromo-3-chlorobenzene undergoes bromine-magnesium exchange reactions with i-PrMgCl-LiCl in THF at 0°C and is strongly accelerated by electron-withdrawing substituents. It acts as test substrate to study the application of a new catalytic system for cyanation of various aryl halides using K4[Fe(CN)6] as cyanating source.
General Description
1-Bromo-3-chlorobenzene undergoes bromine-magnesium exchange reactions with
i-PrMgCl-LiCl in THF at 0°C and is strongly accelerated by electron-withdrawing substituents. It acts as test substrate to study the application of a new catalytic system for cyanation of various aryl halides using K
4[Fe(CN)
6] as cyanating source.
Synthesis
Taking m-chloroaniline as raw material, mixed with concentrated hydrobromic acid, make the temperature drop to 0 , under stirring, quickly add sodium nitrite aqueous solution, make o-chloroaniline nitrogenation, to produce diazonium salts, in the process of the reaction should be controlled the temperature does not exceed 10 . Then use Sandmeyer reaction, add catalyst copper bromide and hydrobromic acid in the reaction system to decompose the diazonium salt, the decomposition reaction is carried out at the boiling temperature, after the reaction is completed, let it stand, take out the organic layer underneath, wash it with water, remove the water by drying and distill it under reduced pressure, m-bromochlorobenzene can be produced.
