Risks to the environment
Climbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms.
Description
(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of
C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of
M. pachydermatis (MICs = <0.06-1 μg/ml) and
M. furfur (MICs = <0.06-0.5 μg/ml)
in vitro. It also reduces the size of
Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.
Chemical Properties
White Solid
Uses
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix.
s assay and did not induce micronuclei in human lymphocytes.
Definition
ChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.
Hazard
Moderately toxic by ingestion. Low toxicity by skin contact.
Flammability and Explosibility
Non flammable
Side effects
May cause localized irritation of the skin with symptoms including redness, rashes and itching.
