Uses
CGP52432 has been used as a γ-aminobutyric acid B (GABA
B) antagonist:
- to study its effects on the simulation of the onset of status epilepticus (SE) in mice
- for voltage-clamp recording in mice neurons
- to study its effects on the GABAB receptor-mediated neurotransmission in guinea pig hippocampus
Definition
ChEBI: 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid is a dichlorobenzene.
Biological Activity
Potent, selective GABA B receptor antagonist (IC 50 = 85 nM).
Biochem/physiol Actions
CGP52432 participates in inhibiting the glycine overflow in the hippocampus.