Chemical Properties
Yellow solid
Uses
The sensitivity of 7-azaindole to its environment is demonstrated and then exploited by studying it and its analogs in peptides and in complexes with larger proteins containing many tryptophan residues.
Synthesis
General procedure for the synthesis of 7-azaindole-4-carboxylic acid from 4-cyano-7-azaindole: A mixture of 4-cyano-7-azaindole (11.5 g, 80 mmol), sodium hydroxide (32 g, 800 mmol), water (100 mL) and ethanol (100 mL) was heated to reflux. After 6 hours of reaction, the reaction mixture was cooled to room temperature, neutralized and acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration to afford 7-azaindole-4-carboxylic acid (10.4 g, 80% yield), which was used in subsequent reactions without further purification.
References
[1] Patent: WO2012/127506, 2012, A1. Location in patent: Page/Page column 65
[2] Patent: WO2011/23081, 2011, A1. Location in patent: Page/Page column 52
