3-Ethynyltoluene

Uses

3-ETHYNYLTOLUENE is a useful research chemical.

Chemical Properties

Clear light yellow to brown liquid

Synthesis Reference(s)

The Journal of Organic Chemistry, 43, p. 358, 1978 DOI: 10.1021/jo00396a046
Tetrahedron Letters, 13, p. 5209, 1972

Synthesis

The general procedure for the synthesis of 3-methylphenylacetylene from 3-tolyl(trimethylsilyl)acetylene was as follows: 3-[(trimethylsilyl)ethynyl]toluene (1 mmol), an inorganic base (potassium tert-butanol, sodium tert-butanol, potassium hydroxide, sodium hydroxide, or potassium trimethylsilylated, sodium trimethylsilylated, 0.05 mmol) were added in turn to a 10 mL sealed tube, as well as 2 mL of DMA or DMSO as solvent. The mixture was heated and stirred in an oil bath at 60 °C for 7 h. The reaction progress was monitored by TLC. Upon completion of the reaction, equal amounts of homotrimethylbenzene or n-undecane were added as internal standards for quantitative analysis of the crude product. The exact yields of the products were determined by GC and GC-MS. The yields of the products were 74%, 73%, 74%, 80%, 93%, and 90% when DMSO was used as the solvent and potassium tert-butanol, sodium tert-butanol, potassium hydroxide, sodium hydroxide, or potassium trimethylmethylsilylated, sodium trimethylmethylsilylated were used as the catalysts, respectively. And when DMA was used as the solvent, the yields of the products were 61%, 60%, 63%, 73%, 82%, and 83%, respectively, using the same catalysts.

References

[1] Journal of Chemical Research, 2007, # 12, p. 728 - 732
[2] Patent: CN107459438, 2017, A. Location in patent: Paragraph 0054; 0055
[3] Organic Letters, 2014, vol. 16, # 3, p. 948 - 951
[4] Tetrahedron Letters, 1972, vol. 13, # 51, p. 5209 - 5212
[5] Organic letters, 2001, vol. 3, # 2, p. 153 - 155