Uses
Dynarrestin is an dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.
Biological Activity
Dynarrestin is a potent and selective reversible inhibitor of cytoplasmic dyneins 1 and 2 th at inhibits dynein 1-dependent microtubule binding and motility without affecting ATP hydrolysis. It inhibits endosome movement and disturbs mitosis in cells. Dynarrestin inhibits dynein 2-mediated intraflagellar transport of the cargo IFT88 and flux of Smo within cilia. Also it inhibits cancer cells proliferation downstream of Smo.', 'Dynarrestin is an aminothiazole derivative, which can bind to protein tyrosine phosphatase interacting protein 51 (PTPIP51). This interaction helps in regulating various signaling pathways th at lead to proliferation and migration. Dynarrestin blocks hedgehog (Hh)-dependent signaling in mouse and human cells.
