Chemical Properties
Off-White Solid
Uses
19-Hydroxyandrostendione is a novel substituted estrogen as aromatase inhibitor. It induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olactory receptor.
Definition
ChEBI: 19-hydroxyandrost-4-ene-3,17-dione is a 19-hydroxy steroid, a 3-oxo steroid, a 17-oxo steroid and an androstanoid. It has a role as a mouse metabolite.
Purification Methods
Recrystallise 19-hydroxy-4-androsten-3,17-dione from Me2CO/hexane or Et2O/hexane. It has UV with max at 242nm in EtOH or MeOH. The 19-acetoxy derivative has [] 26D +185o (CHCl3) and max 237.5nm in EtOH. [Ehrenstein & Dünnenberger J Org Chem 21 774 1956, Beilstein 8 IV2162.]