Synthesis
GENERAL STEPS: Benzyl bromide (0.052 mL, 0.6 mmol) was added to a mixture of 6-chloropurine (0.056 g, 0.5 mmol) and sodium hydroxide (0.014 g, 0.6 mmol) in deionized water (2 mL). The reaction mixture was placed in a microwave reactor and irradiated at 0-400 W power (internal temperature maintained at 100 °C) for 10 min. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent and the residue was purified by column chromatography using ethyl acetate-cyclohexane (9:1, v/v) as eluent to give 9-benzyl-6-chloro-9H-purine in 82% yield.
References
[1] Nucleosides, Nucleotides and Nucleic Acids, 2016, vol. 35, # 2, p. 76 - 82
[2] European Journal of Medicinal Chemistry, 2004, vol. 39, # 5, p. 433 - 447
[3] Journal of Medicinal Chemistry, 1988, vol. 31, # 3, p. 606 - 612
[4] Tetrahedron Letters, 2014, vol. 55, # 18, p. 2929 - 2931
[5] Dalton Transactions, 2014, vol. 43, # 26, p. 9838 - 9842
