Dichloro(1,5-cyclooctadiene)platinum(II)

Chemical Properties

white to pale yellow

Uses

it is used in Hydrosilyation reactions.

Uses

Catalyst for:

• Hydrogenative cyclization of allenynes
• Stereoselective tandem hydrosilylation-Hiyama coupling reactions
• Amino alkene cyclohydroamination
• Hydrative cyclization reactions
• Direct amination of allylic alcohols under mild conditions

• Potential anticancer agent

reaction suitability

core: platinum
reagent type: catalyst

Synthesis

2.1.4.1 Synthesis of cis-dichloro(1,5-cyclooctadiene)platinum(II), [Pt(cod)Cl2] (0014): K2PtCl4 (1.000 g, 2.4 mmol) was dissolved in water (16 mL) and the resulting solution was filtered. Acetic acid (24 mL) and 1,5-cyclooctadiene (cod) (1.00 mL, 8.1 mmol) were sequentially added to the filtrate under light protection. The reaction mixture was stirred and heated in a water bath at about 100°C. Within 30 minutes, the dark red solution gradually changed to a pale yellow color with the formation of a precipitate. After about 2 h, the solution was concentrated to a volume of 10 mL by distillation under reduced pressure, after which the resulting precipitate was separated by centrifugation and washed sequentially with water, ethanol and ether. Product yield: 703 mg (80%).1H NMR (CDCl3) δ: 5.60 (4H, t, CH), 2.70 (2H, m, CH2-CH), 2.30-2.16 (2H, m, CH2-CH) ppm; 13C{1H} NMR (CDCl3) δ: 100.0 (CH), 30.0 (CH2) ppm. 195Pt NMR (CDCl3) δ: -3340 ppm.

References

[1] Chemistry - An Asian Journal, 2018, vol. 13, # 8, p. 1053 - 1059
[2] Dalton Transactions, 2008, # 47, p. 6724 - 6731
[3] Organometallics, 2014, vol. 33, # 15, p. 4027 - 4034
[4] Journal of the American Chemical Society, 2015, vol. 137, # 42, p. 13464 - 13467
[5] Journal of Inorganic Biochemistry, 2016, vol. 160, p. 275 - 286