4-Hydroxyphenyl 4-Methoxyphenyl ketone

Uses

4-Hydroxy-4''-methoxybenzophenone is an intermediate in the synthesis of Nitromifene Citrate (E/Z mixture) (N496700). Nitromifene Citrate s a non-steroidal estrogen antagonist. It is structurally similar to Tamoxifen (T006000) which is a selective estrogen response modifier (SERM).

Preparation

Preparation by reduction of 4-methoxy- 4?-nitro-benzophenone with stannous chloride and hydrochloric acid, followed by diazotization of the resulting 4-amino-4?-methoxybenzophenone and hydrolysis of the diazonium salt.