Description
PluriSln-1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln-1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated cells.1?The ability to eliminate potentially tumorigenic undifferentiated cells is important for increasing the safety of hPSC-based treatments. PluriSln-1 has been used to successfully eliminate tumorigenic cells in cardiomyocytes2?and chondrogenic cells3.
Uses
NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.
References
1) Ben-David?et al. (2013),?Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen; Cell Stem Cell.?12?167
2) Zhang?et al. (2014),?Inhibition of stearoyl-coA desaturase eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium; Cell Cycle?13?762
3) Cheng?et al. (2014),?Cartilage Repair Using Human Embryonic Stem Cell-Derived Chondroprogenitors; Stem Cells Transl. Med.?3?1287
