Description
An Alstonia alkaloid obtained from A. scholaris R. Br., this base also occurs in
Rauwolfia vornitora. It has [α]
D - 47° (CHCI3). The ultraviolet spectrum in
neutral solution (EtOH) has absorption maxima at 237 and 287 mil, while in
acidic solution (perchloric acid), there are absorption maxima at 239, 244 and
305 mil. A methoxycarbonyl group, an alkyl group and an ether bridge are present
in the molecule. The picrate is obtained as light yellow crystals with m.p. 172-
4°C (dec.) and the methiodide has m.p. 235-7°C.
Uses
Picrinine is a monoterpenoid indole alkaloid extracted from Ochrosia elliptica, displaing the enhancement of immunomodulatory activity and apaptosis inducing in the A549 cell lines.
References
Preparation:
Britten, Smith.,J. Chern. Soc., 3850 (1963)
Isolation:
Chatterjee et al., Tetrahedron Lett., 3633 (1965)
