CALYCULIN A

Uses

Calyculin A is a PP1 and PP2A-C inhibitor and tumor inducer.

Uses

Calyculin A from Discodermia calyx has been used:

• as an inhibitor of serine-threonine protein phosphatase 2A
• as an inhibitor of cyclin D1 phosphatase in human breast cancer cells
• as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells

Uses

Inhibitor of phosphatases 1 and 2a.

General Description

Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da.

Biological Activity

Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC 50 = 0.3-0.7 nM) and protein phosphatase 2A (IC 50 = 0.5-1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Biochem/physiol Actions

Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.

storage

Store at -20°C