Chemical Properties
Yellow Crystalline Solid
Uses
A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist.
Uses
N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.
Uses
A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist.
Definition
ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
General Description
N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril
? and FrazaClo in the US. This Certified Snap-N-Spike
? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.
Biological Activity
A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist.
Biochem/physiol Actions
N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.
